Highly luminescent gold nanoparticles: effect of ruthenium distance for nanoprobes with enhanced lifetimes.

High coating of Ru(II) complexes on gold nanoparticles for single particle luminescence imaging in cells.

Gold nanoparticles are efficiently labelled with a luminescent ruthenium complex, producing 13 and 100 nm diameter, monodisperse red-emissive imaging probes with luminescence lifetimes prolonged over the molecular unit. Single, 100 nm particles are observed in whole cell luminescence imaging which reveals their biomolecular association with chromatin in the nucleus of cancer cells.

Dual modal in vivo imaging using upconversion luminescence and enhanced computed tomography properties.

In vivo upconversion luminescence (UCL) imaging, exhibiting favorable characteristics such as high photostability, no blinking, sharp emission lines, and long lifetimes, is recognized as the excellent and significant photoluminescence imaging for the future. To develop the imaging system with high visual sensitivity and tissue penetration, the functional molecules with X-ray computed tomography...

Folic acid-modified diatrizoic acid-linked dendrimer-entrapped gold nanoparticles as nanoprobes for targeted CT imaging of human cervical cancer

Gold and Hairpin DNA Functionalization of Upconversion Nanocrystals for Imaging and In Vivo Drug Delivery.

Although multifunctional upconversion imaging probes have recently attracted considerable interest in biomedical research, there are currently few methods for stabilizing these luminescent nanoprobes with oligonucleotides in biological systems. Herein, a method to robustly disperse upconversion nanoprobes in physiological buffers based on rational design and synthesis of nanoconjugates comprisi...

Evaluation of multifunctional targeted gold nanoparticles on X-ray attenuation in nasopharyngeal cancer cells by X- ray imaging

Introduction: Head-and-neck cancer is the sixth most common cancer worldwide with the number of cases consistently increasing in developing countries. Successful development of effective, safe and cost effective nanoprobes for head-and-neck cancer targeting imaging is a big challenge. This study is aimed to develop cysteamine-folate conjugated gold nanoparticles (F-Cys-AuNPs) a...